my otp ginhiji/hijigin... but i love takahiji,ginsaka,ginzura,gintaka etc...
I really don't do pairings with Gintama, but if I did, I would say Gintoki x Tsukuyo, or even Otae x Kyuubei. I just don't see any male x male pairings in this series, but it's likely because I ship based on interactions between characters that imply romantic feelings, rather than hotness/sexiness. If superficial reasons, such as looks, were the case, I'd have almost the entire cast in a full blown orgy. XD
Gintokixhijikata!!!! <3
Tsukuo x Jyuubei...it could happen.