Hmm! Well, what I can suggest, is to make sure TnC is NOT installed in the default location. The default location is
C:\Program Files (x86)\NitroplusCHiRAL\咎狗の血\ But because TnC is an older game, it's going to try to save it's files in the same folder. Windows HATES that, so install the game somewhere else. For example, my TnC is installed to
C:\Games\NitroplusCHiRAL\咎狗の血\ ^^
Doing this will also help with the English patch, which sometimes won't work in the default location.
Lastly, there was a Windows update back in September that nuked TnC. It won't start at all. The version of TnC that's on the internet is supposed to check the CD Drive to see if the disk is in there, but Windows nuked that functionality.
Instead, I offer you a NoCD version of the EXE, that was made for Windows Vista (So it'll work on 7, 8 and 10):
https://mega.nz/#!dJp0RSKa!V7MPzzWuJ..._oLbM5QJF-eVls
Download this and extract this EXE, OVERWRITE the EXE in the installation folder.
It might work in the default location, I haven't tried that myself as I never install to the default location. o.o Do let me know if you try that, however, and if it works.
Good luck!