I also had this problem. Here's how I solved it:
1. Restart your computer.
2. Open your Nitro+Chiral folder and then your DRAMAtical Murder folder.
3. Click on the crack.exe you added to your folder to run the game, DO NOT chose DMMD.exe and then the crack, it won't run and you'll get an error message. If you don't have the crack.exe to properly run the game, please download the update and crack. Copy over the update replacing old files, and then add the crack.
4. If you still have the error message, something else has gone wrong. Is there a ".dll" somewhere in the error message?
---------- Post added at 11:44 PM ---------- Previous post was at 11:42 PM ----------
This happens when your computer can't load the Japanese Text for the 2 warning boxes that pop up before the game starts.
You must change your System Locale.
Change your System Locale to Japanese. This will not affect your computer in any major ways. You can always switch it back.
"
If the problem still persists you might have to restart your computer to make it work.
- Open Regional and Language Options by clicking the Start button , clicking Control Panel, clicking Clock, Language, and Region, and then clicking Regional and Language Options.
- Click the Administrative tab, and then, under Language for non-Unicode programs (System Locale), click Change system locale. If you are prompted for an administrator password or confirmation, type the password or provide confirmation.
- Select the language, and then click OK."
If you've already solved this I apologize for bumping an old post.